Quinoline and quinolones: promising scaffolds for future antimycobacterial agents
نویسندگان
چکیده
منابع مشابه
Novel quinoline and naphthalene derivatives as potent antimycobacterial agents.
We have designed and synthesized both the quinoline and naphthalene based molecules influenced by the unique structural make-up of mefloquine and TMC207, respectively. These compounds were evaluated for their anti-mycobacterial activity against drug sensitive Mycobacterium tuberculosis H37Rv in vitro at single-dose concentration (6.25 microg/mL). The compounds 22, 23, 26 and 27 inhibited the gr...
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Chemistry Dept., Pharmaceutical Research Institute, Rydygiera St. 8, 01-793 Warszawa; Faculty of Biotechnology, Wrocław University, Fryderyk Joliot-Curie St. 14a, 50-383 Wrocław; Faculty of Chemistry, Wroclaw University of Technology, C.K. Norwid St.4/6, 50373 Wrocław; Experimental Acticancer Therapy Laboratory, Institute of Immunology and Experimental Therapy of Polish Academy of Sciences, Rud...
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Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
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Recent developments on antimicrobial quinoline chemistry were shortly reviewed covering six important topics: Historical aspects of the quinoline-based antimicrobial drug development; Increasing resistance problems and reasons for developing new antimicrobial agents; Molecular quinoline-based hybrids in the design and development of novel antimicrobial agents; Structural evolution of the quinol...
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The quinolone class of antimicrobial agents has generated considerable interest since its discovery >40 years ago. Substantial progress has been made in our understanding of the molecular mechanisms of the action of quinolones against pathogenic bacteria, the induction of resistance to quinolones in these organisms, and the potential of each quinolone compound to induce toxicity in treated pati...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2014
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2014.930454